Cruises from Rome to Istanbul

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Cruises from Rome to Istanbul

We found you 58 cruises

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Queen Victoria (Photo: Cunard Cruise Line)
Queen Victoria
Queen Victoria Cabins
Queen Victoria
Queen Victoria Dining
Queen Victoria
Queen Victoria Activity/Entertainment
Queen Victoria
Queen Victoria
Queen Victoria

14 Nights

Mediterranean - Eastern Cruise

Port: Rome • Taormina • Rhodes • Kusadasi • Dardanelles Strait • Istanbul • +5 more

583 reviews
May 13, 2024
Cunard Line
Cunard Line
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Queen Victoria (Photo: Cunard Cruise Line)
Queen Victoria
Queen Victoria Cabins
Queen Victoria
Queen Victoria Dining
Queen Victoria
Queen Victoria Activity/Entertainment
Queen Victoria
Queen Victoria
Queen Victoria

7 Nights

Mediterranean - Eastern Cruise

Port: Rome • Taormina • Rhodes • Kusadasi • Dardanelles Strait • Istanbul

583 reviews
Cunard Line
Cunard Line
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14 Nights

Ancient Mysteries & Egypt

Port: Rome • Katakolon • Chania, Crete • Istanbul • Izmir • Kusadasi • Rhodes • Limassol • Cairo • +2 more

269 reviews
Sep 21, 2024
Holland America Line
Holland America Line
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10 Nights

Greece, Turkey & Italy Cruise

Port: Rome • Naples • Santorini • Athens • Kusadasi • Istanbul • Rome

122 reviews
Oct 12, 2025
Royal Caribbean International
Royal Caribbean International
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Cruise Critic Favorite

14 Nights

Mediterranean - Eastern Cruise

Port: Rome • Rhodes • Kusadasi • Dardanelles Strait • Istanbul • Dardanelles Strait • Santorini • +3 more

583 reviews
May 12, 2025
Cunard Line
Cunard Line
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7 Nights

Mediterranean Cruise

Port: Rome • Naples • Santorini • Istanbul • Mykonos • Athens

11 reviews
Princess Cruises
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28 Nights

Ancient Mysteries & Eternal Cities

Port: Rome • Katakolon • Chania, Crete • Istanbul • Izmir • Kusadasi • Rhodes • Limassol • Cairo • +14 more

269 reviews
Sep 21, 2024
Holland America Line
Holland America Line
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20 Nights

Mediterranean Cruise

Port: Rome • Naples • Taormina • Malta • Chania • Kotor • Dubrovnik • Split • Trieste • Dubrovnik • +5 more

732 reviews
Princess Cruises
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11 Nights

Greek Isles & Italy

Port: Rome • Florence • Naples • Taormina • Crete • Santorini • Kusadasi • Istanbul • Mykonos • +2 more

2,402 reviews
May 20, 2025
Norwegian Cruise Line
Norwegian Cruise Line
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11 Nights

Mediterranean Cruise

Port: Rome • Palermo • Malta • Athens • Strait of the Dardanelles • Istanbul • Mykonos • +5 more

162 reviews
Jun 3, 2024
Costa Cruises
Costa Cruises
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21 Nights

Mediterranean Cruise

Port: Rome • Naples • Chania • Istanbul • Mykonos • Athens • Kotor • Corfu • Taormina • +6 more

11 reviews
Sep 6, 2025
Princess Cruises
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14 Nights

Mediterranean Cruise

Port: Rome • Naples • Santorini • Istanbul • Mykonos • Athens • Kotor • Corfu • Taormina • Naples • +1 more

11 reviews
Princess Cruises
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14 Nights

Ancient Mediterranean Antiquities

Port: Rome • Naples • Sicily • Ionian Sea • Crete • Kusadasi • Athens • Agios Nikolaos • Rhodes • +3 more

429 reviews
Apr 8, 2026
Viking Ocean Cruises
Viking Ocean Cruises
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14 Nights

Mediterranean Cruise

Port: Rome • Naples • Chania • Istanbul • Mykonos • Athens • Kotor • Corfu • Taormina • +2 more

11 reviews
Sep 6, 2025
Princess Cruises
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21 Nights

Malta Sicily Athens & Adriatic: Naples & Mykonos

Port: Rome • Naples • Taormina • Malta • Kotor • Kefalonia • Argostoli • Chania, Crete • +10 more

1,087 reviews
May 29, 2025
Holland America Line
Holland America Line
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